Evaluation of dynamic weight bearing for measuring nonevoked inflammatory hyperalgesia in mice.

ABSTRACT:

Background

Animal models in pain research have suggested that inclusion of both evoked and nonevoked behavioral measures is needed to better reflect the human pain experience. Individuals with chronic pain are known to experience spontaneous pain, in addition to pain after exposure to an external stimulus. Recently, the dynamic weight bearing (DWB) apparatus was developed to assess for nonevoked hyperalgesia by capturing weight bearing and surface distribution in the paws of mice after acute inflammation.

Objectives

The aim of this study was to evaluate the DWB test as a measure of nonevoked hyperalgesia.

Methods

The experimental group received an intraplantar injection in the left hind paw of the inflammatory agent--complete Freund's adjuvant (CFA)--whereas the vehic

SUBMITTER: Griffioen MA 

PROVIDER: S-EPMC4351786 | biostudies-literature | 2015 Mar-Apr

REPOSITORIES: biostudies-literature