Gene by Social-Environment Interaction for Youth Delinquency and Violence: Thirty-Nine Aggression-related Genes.

ABSTRACT: Complex human traits are likely to be affected by many environmental and genetic factors, and the interactions among them. However, previous gene-environment interaction (G×E) studies have typically focused on one or only a few genetic variants at a time. To provide a broader view of G×E, this study examines the relationship between 403 genetic variants from 39 genes and youth delinquency and violence. We find evidence that low social control is associated with greater genetic risk for delinquency and violence and high/moderate social control with smaller genetic risk for delinquency and violence. Our findings are consistent with prior G×E studies based on a small number of genetic variants, and, more importantly, we show that these findings still hold when a large number of genetic varian

SUBMITTER: Liu H 

PROVIDER: S-EPMC4351803 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature