HERV-K(HML-2) rec and np9 transcripts not restricted to disease but present in many normal human tissues.

ABSTRACT:

Background

Human endogenous retroviruses of the HERV-K(HML-2) group have been associated with the development of tumor diseases. Various HERV-K(HML-2) loci encode retrovirus-like proteins, and expression of such proteins is upregulated in certain tumor types. HERV-K(HML-2)-encoded Rec and Np9 proteins interact with functionally important cellular proteins and may contribute to tumor development. Though, the biological role of HERV-K(HML-2) transcription and encoded proteins in health and disease is less understood. We therefore investigated transcription specifically of HERV-K(HML-2) rec and np9 mRNAs in a panel of normal human tissues.

Results

We obtained evidence for rec and np9 mRNA being present in all examined 16 normal tissue types. A total of 18 different HERV-K(HML-2

SUBMITTER: Schmitt K 

PROVIDER: S-EPMC4351823 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature