Neurotensin promotes the progression of malignant glioma through NTSR1 and impacts the prognosis of glioma patients.

ABSTRACT:

Background

The poor prognosis and minimally successful treatments of malignant glioma indicate a challenge to identify new therapeutic targets which impact glioma progression. Neurotensin (NTS) and its high affinity receptor (NTSR1) overexpression induces neoplastic growth and predicts the poor prognosis in various malignancies. Whether NTS can promote the glioma progression and its prognostic significance for glioma patients remains unclear.

Methods

NTS precursor (ProNTS), NTS and NTSR1 expression levels in glioma were detected by immunobloting Elisa and immunohistochemistry assay. The prognostic analysis was conducted from internet by R2 microarray platform. Glioma cell proliferation was evaluated by CCK8 and BrdU incorporation assay. Wound healing model and Matrigel trans

SUBMITTER: Ouyang Q 

PROVIDER: S-EPMC4351837 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature