A genetic risk score for hypertension associates with the risk of ischemic stroke in a Swedish case-control study.

ABSTRACT: Genetic risk scores (GRS), summing up the total effect of several single-nucleotide polymorphisms (SNPs) in genes associated with either coronary risk or cardiovascular risk factors, have been tested for association with ischemic stroke with conflicting results. Recently an association was found between a GRS based on 29 SNPs discovered by genome-wide association studies and hypertension. The aim of our study was to investigate the possible association of the same GRS with ischemic stroke on top of other 'traditional risk factors', also testing its potential improvement in indices of discrimination and reclassification, in a Swedish case-control study. Twenty-nine SNPs were genotyped in 3677 stroke cases and 2415 controls included in the Lund Stroke Register (LSR), the Malmö Diet and Cance

SUBMITTER: Fava C 

PROVIDER: S-EPMC4351890 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature