Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans.

ABSTRACT:

Background

African Americans (AA) have more pronounced insulin resistance and higher insulin secretion than European Americans (Caucasians or CA) when matched for age, gender, and body mass index (BMI). We hypothesize that physiological differences (including insulin sensitivity [SI]) between CAs and AAs can be explained by co-regulated gene networks in tissues involved in glucose homeostasis.

Methods

We performed integrative gene network analyses of transcriptomic data in subcutaneous adipose tissue of 99 CA and 37 AA subjects metabolically characterized as non-diabetic, with a range of SI and BMI values.

Results

Transcripts negatively correlated with SI in only the CA or AA subjects were enriched for inflammatory response genes and integrin-signaling genes, respecti

SUBMITTER: Das SK 

PROVIDER: S-EPMC4351975 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature