PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease.

ABSTRACT:

Objective

To minimize pathologic heterogeneity in genetic studies of Parkinson disease (PD), the Autopsy-Confirmed Parkinson Disease Genetics Consortium conducted a genome-wide association study using both patients with neuropathologically confirmed PD and controls.

Methods

Four hundred eighty-four cases and 1,145 controls met neuropathologic diagnostic criteria, were genotyped, and then imputed to 3,922,209 variants for genome-wide association study analysis.

Results

A small region on chromosome 1 was strongly associated with PD (rs10788972; p = 6.2 × 10(-8)). The association peak lies within and very close to the maximum linkage peaks of 2 prior positive linkage studies defining the PARK10 locus. We demonstrate that rs10788972 is in strong linkage disequilibrium wit

SUBMITTER: Beecham GW 

PROVIDER: S-EPMC4352096 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature