Long-term efficacy and safety of thalamic stimulation for drug-resistant partial epilepsy.

ABSTRACT:

Objective

To report long-term efficacy and safety results of the SANTE trial investigating deep brain stimulation of the anterior nucleus of the thalamus (ANT) for treatment of localization-related epilepsy.

Methods

This long-term follow-up is a continuation of a previously reported trial of 5- vs 0-V ANT stimulation. Long-term follow-up began 13 months after device implantation with stimulation parameters adjusted at the investigators' discretion. Seizure frequency was determined using daily seizure diaries.

Results

The median percent seizure reduction from baseline at 1 year was 41%, and 69% at 5 years. The responder rate (≥50% reduction in seizure frequency) at 1 year was 43%, and 68% at 5 years. In the 5 years of follow-up, 16% of subjects were seizure-free for at

SUBMITTER: Salanova V 

PROVIDER: S-EPMC4352097 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature