Long-term disability after lacunar stroke: secondary prevention of small subcortical strokes.

ABSTRACT:

Objectives

To determine whether vascular and demographic factors predict worsening disability up to 8 years after lacunar stroke.

Methods

SPS3 (Secondary Prevention of Small Subcortical Strokes) was a clinical trial in lacunar stroke patients with annual assessment of disability using the Older Americans Resources and Survey instrumental activities of daily living (IADL) scale (range 0-14). Generalized estimating equations modeled the likelihood of disability (IADL <14) over time, adjusting for demographics, medical risk factors, cognition, mood, stroke location, and geographic region in univariate and multivariable models. IADL assessments after recurrent stroke were censored. We stratified by study region and age quartile.

Results

Among 2,820 participants, mean age

SUBMITTER: Dhamoon MS 

PROVIDER: S-EPMC4352098 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature