Oxidative balance score and risk for incident prostate cancer in a prospective U.S. cohort study.

ABSTRACT:

Purpose

Oxidative stress is defined as an imbalance between pro-oxidants and antioxidants. Previous research found that a single comprehensive oxidative balance score (OBS) that includes individual pro- and anti-oxidant exposures may be associated with various conditions (including prostate cancer) in the absence of associations with the individual factors. We investigated an OBS-incident prostate cancer association among 43,325 men in the Cancer Prevention Study II Nutrition Cohort.

Methods

From 1999-2007, 3386 incident cases were identified. Twenty different components, used in two ways (unweighted or weighted based on literature reviews), were incorporated into the OBS, and the resulting scores were then expressed as three types of variables (continuous, quartiles, or six

SUBMITTER: Lakkur S 

PROVIDER: S-EPMC4352102 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature