Selective targeting of Toll-like receptors and OX40 inhibit regulatory T-cell function in follicular lymphoma.

ABSTRACT: Immunotherapeutic strategies are promising approaches for the treatment of follicular lymphoma (FL). However, their efficacy may be limited by immunosuppressive elements in the immune system and tumor microenvironment. Therefore, strategies to reverse the effects of the immunosuppressive elements are needed. We observed that regulatory T cells (Tregs) were increased in the peripheral blood at diagnosis and persisted in high numbers after induction of clinical remission with a cyclophosphamide and doxorubicin-containing chemotherapy regimen in FL patients. High levels of peripheral blood Tregs prior to therapy were associated with decreased progression-free survival in FL patients treated with either chemotherapy or combination immunotherapy that targeted CD20 and PD-1 with monoclonal antib

SUBMITTER: Voo KS 

PROVIDER: S-EPMC4352105 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature