Identification and utilization of donor and recipient genetic variants to predict survival after HCT: are we ready for primetime?

ABSTRACT: Overall survival following hematopoietic cell transplantation (HCT) has improved over the past two decades through better patient selection and advances in HLA typing, supportive care, and infection prophylaxis. Nonetheless, mortality rates are still unsatisfactory and transplant-related mortality remains a major cause of death after unrelated allogeneic HCT. Since there are no known pre-HCT, non-HLA biologic predictors of survival following transplant, for over a decade, scientists have been investigating the role of non-HLA germline genetic variation in survival and treatment-related mortality after HCT. Variation in single nucleotide polymorphisms (SNPs) has the potential to impact chemotherapy, radiation, and immune responses, leading to different post-HCT survival outcomes. In this pa

SUBMITTER: Sucheston-Campbell LE 

PROVIDER: S-EPMC4352187 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature