Genetic diversity of the 2013-14 human isolates of influenza H7N9 in China.

ABSTRACT:

Background

Influenza H7N9 has become an endemic pathogen in China where circulating virus is found extensively in wild birds and domestic poultry. Two epidemic waves of Human H7N9 infections have taken place in Eastern and South Central China during the years of 2013 and 2014. In this study, we report on the first four human cases of influenza H7N9 in Shantou, Guangdong province, which occurred during the second H7N9 wave, and the subsequent analysis of the viral isolates.

Methods

Viral genomes were subjected to multisegment amplification and sequenced in an Illumina MiSeq. Later, phylogenetic analyses of influenza H7N9 viruses were performed to establish the evolutionary context of the disease in humans.

Results

The sequences of the isolates from Shantou have closer

SUBMITTER: Farooqui A 

PROVIDER: S-EPMC4352237 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature