Biosynthesis and transport of the lantibiotic mutacin 1140 produced by Streptococcus mutans.

ABSTRACT:

Unlabelled

Lantibiotics are ribosomally synthesized peptide antibiotics composed of an N-terminal leader peptide that is cleaved to yield the active antibacterial peptide. Significant advancements in molecular tools that promote the study of lantibiotic biosynthesis can be used in Streptococcus mutans. Herein, we further our understanding of leader peptide sequence and core peptide structural requirements for the biosynthesis and transport of the lantibiotic mutacin 1140. Our study on mutacin 1140 biosynthesis shows a dedicated secondary cleavage site within the leader peptide and the dependency of transport on core peptide posttranslational modifications (PTMs). The secondary cleavage site on the leader peptide is found at the -9 position, and secondary cleavage occurs before the

SUBMITTER: Escano J 

PROVIDER: S-EPMC4352662 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature