The enhancer binding protein Nla6 regulates developmental genes that are important for Myxococcus xanthus sporulation.

ABSTRACT:

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In the bacterium Myxococcus xanthus, starvation triggers the formation of multicellular fruiting bodies containing thousands of stress-resistant spores. Recent work showed that fruiting body development is regulated by a cascade of transcriptional activators called enhancer binding proteins (EBPs). The EBP Nla6 is a key component of this cascade; it regulates the promoters of other EBP genes, including a downstream-functioning EBP gene that is crucial for sporulation. In recent expression studies, hundreds of Nla6-dependent genes were identified, suggesting that the EBP gene targets of Nla6 may be part of a much larger regulon. The goal of this study was to identify and characterize genes that belong to the Nla6 regulon. Accordingly, a direct repeat [consensus, C(C/A)ACG

SUBMITTER: Giglio KM 

PROVIDER: S-EPMC4352671 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature