Syphilis in HIV-infected mothers and infants: results from the NICHD/HPTN 040 study.

ABSTRACT:

Background

Untreated syphilis during pregnancy is associated with spontaneous abortion, stillbirth, prematurity and infant mortality. Syphilis may facilitate HIV transmission, which is especially concerning in low- and middle-income countries where both diseases are common.

Methods

We performed an analysis of data available from NICHD/HPTN 040 (P1043), a study focused on the prevention of intrapartum HIV transmission to 1684 infants born to 1664 untreated HIV-infected women. This analysis evaluates risk factors and outcomes associated with a syphilis diagnosis in this cohort of HIV-infected women and their infants.

Results

Approximately, 10% of women (n=171) enrolled had serological evidence of syphilis without adequate treatment documented and 1.4% infants (n=24) wer

SUBMITTER: Yeganeh N 

PROVIDER: S-EPMC4352722 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature