SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx.

ABSTRACT: Neutrophils cast neutrophil extracellular traps (NETs) to defend the host against invading pathogens. Although effective against microbial pathogens, a growing body of literature now suggests that NETs have negative impacts on many inflammatory and autoimmune diseases. Identifying mechanisms that regulate the process termed "NETosis" is important for treating these diseases. Although two major types of NETosis have been described to date, mechanisms regulating these forms of cell death are not clearly established. NADPH oxidase 2 (NOX2) generates large amounts of reactive oxygen species (ROS), which is essential for NOX-dependent NETosis. However, major regulators of NOX-independent NETosis are largely unknown. Here we show that calcium activated NOX-independent NETosis is fast and mediate

SUBMITTER: Douda DN 

PROVIDER: S-EPMC4352781 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature