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Control of a hair bundle's mechanosensory function by its mechanical load.

ABSTRACT: Hair cells, the sensory receptors of the internal ear, subserve different functions in various receptor organs: they detect oscillatory stimuli in the auditory system, but transduce constant and step stimuli in the vestibular and lateral-line systems. We show that a hair cell's function can be controlled experimentally by adjusting its mechanical load. By making bundles from a single organ operate as any of four distinct types of signal detector, we demonstrate that altering only a few key parameters can fundamentally change a sensory cell's role. The motions of a single hair bundle can resemble those of a bundle from the amphibian vestibular system, the reptilian auditory system, or the mammalian auditory system, demonstrating an essential similarity of bundles across species and receptor organs.

SUBMITTER: Salvi JD

PROVIDER: S-EPMC4352782 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Control of a hair bundle's mechanosensory function by its mechanical load.

Salvi Joshua D JD Ó Maoiléidigh Dáibhid D Fabella Brian A BA Tobin Mélanie M Hudspeth A J AJ

Proceedings of the National Academy of Sciences of the United States of America 20150217 9

Hair cells, the sensory receptors of the internal ear, subserve different functions in various receptor organs: they detect oscillatory stimuli in the auditory system, but transduce constant and step stimuli in the vestibular and lateral-line systems. We show that a hair cell's function can be controlled experimentally by adjusting its mechanical load. By making bundles from a single organ operate as any of four distinct types of signal detector, we demonstrate that altering only a few key param ...[more]

PMID: 25691749

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