Cobalt-promoted dimerization of aminoquinoline benzamides.

ABSTRACT: A method for aminoquinoline-directed, cobalt-promoted dimerization of benzamides has been developed. Reactions proceed in ethanol solvent in the presence of Mn(OAc)2 cocatalyst and Na2CO3 base and use oxygen as a terminal oxidant. Bromo, iodo, nitro, ether, and ester moieties are compatible with the reaction conditions. Cross-coupling of electronically dissimilar aminoquinoline benzamides proceeds with modest yields and selectivities.

SUBMITTER: Grigorjeva L 

PROVIDER: S-EPMC4352950 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature