Long Non-Coding RNA Expression during Aging in the Human Subependymal Zone.

ABSTRACT: The human subependymal zone (SEZ) is debatably a source of newly born neurons throughout life and neurogenesis is a multi-step process requiring distinct transcripts during cell proliferation and early neuronal maturation, along with orchestrated changes in gene expression during cell state/fate transitions. Furthermore, it is becoming increasingly clear that the majority of our genome that results in production of non-protein-coding RNAs plays vital roles in the evolution, development, adaptation, and region-specific function of the human brain. We predicted that some transcripts expressed in the SEZ may be unique to this specialized brain region, and that a comprehensive transcriptomic analysis of this region would aid in defining expression changes during neuronal birth and growth in ad

SUBMITTER: Barry G 

PROVIDER: S-EPMC4353253 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature