Patient controlled analgesia with remifentanil versus epidural analgesia in labour: randomised multicentre equivalence trial.

ABSTRACT: OBJECTIVE:To determine women's satisfaction with pain relief using patient controlled analgesia with remifentanil compared with epidural analgesia during labour. DESIGN:Multicentre randomised controlled equivalence trial. SETTING:15 hospitals in the Netherlands. PARTICIPANTS:Women with an intermediate to high obstetric risk with an intention to deliver vaginally. To exclude a clinically relevant difference in satisfaction with pain relief of more than 10%, we needed to include 1136 women. Because of missing values for satisfaction this number was increased to 1400 before any analysis. We used multiple imputation to correct for missing data. INTERVENTION:Before the onset of active labour consenting women were randomised to a pain relief strategy with patient controlled remifentanil or epidu

SUBMITTER: Freeman LM 

PROVIDER: S-EPMC4353278 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature