Improving diabetes prevention with benefit based tailored treatment: risk based reanalysis of Diabetes Prevention Program.

ABSTRACT:

Objective

To determine whether some participants in the Diabetes Prevention Program were more or less likely to benefit from metformin or a structured lifestyle modification program.

Design

Post hoc analysis of the Diabetes Prevention Program, a randomized controlled trial.

Setting

Ambulatory care patients.

Participants

3060 people without diabetes but with evidence of impaired glucose metabolism.

Intervention

Intervention groups received metformin or a lifestyle modification program with the goals of weight loss and physical activity.

Main outcome measure

Development of diabetes, stratified by the risk of developing diabetes according to a diabetes risk prediction model.

Results

Of the 3081 participants with impaired glucose metabolism at

SUBMITTER: Sussman JB 

PROVIDER: S-EPMC4353279 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature