Urine neutrophil gelatinase-associated lipocalin and risk of cardiovascular disease and death in CKD: results from the Chronic Renal Insufficiency Cohort (CRIC) Study.

ABSTRACT:

Background

Chronic kidney disease is common and is associated with increased cardiovascular disease risk. Currently, markers of renal tubular injury are not used routinely to describe kidney health and little is known about the risk of cardiovascular events and death associated with these biomarkers independent of glomerular filtration-based markers (such as serum creatinine or albuminuria).

Study design

Cohort study, CRIC (Chronic Renal Insufficiency Cohort) Study.

Setting & participants

3,386 participants with estimated glomerular filtration rate of 20 to 70mL/min/1.73m(2) enrolled from June 2003 through August 2008.

Predictor

Urine neutrophil gelatinase-associated lipocalin (NGAL) concentration.

Outcomes

Adjudicated heart failure event, ischemic ather

SUBMITTER: Liu KD 

PROVIDER: S-EPMC4353671 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature