The DNA methylation drift of the atherosclerotic aorta increases with lesion progression.

ABSTRACT:

Background

Atherosclerosis severity-independent alterations in DNA methylation, a reversible and highly regulated DNA modification, have been detected in aortic atheromas, thus supporting the hypothesis that epigenetic mechanisms participate in the pathogenesis of atherosclerosis. One yet unaddressed issue is whether the progression of atherosclerosis is associated with an increase in DNA methylation drift in the vascular tissue. The purpose of the study was to identify CpG methylation profiles that vary with the progression of atherosclerosis in the human aorta.

Methods

We interrogated a set of donor-matched atherosclerotic and normal aortic samples ranging from histological grade III to VII, with a high-density (>450,000 CpG sites) DNA methylation microarray.

Results

SUBMITTER: Valencia-Morales Mdel P 

PROVIDER: S-EPMC4353677 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature