Ascaris, atopy, and exercise-induced bronchoconstriction in rural and urban South African children.

ABSTRACT:

Background

Populations with endemic parasitosis have high levels of IgE but low levels of allergic disease. We investigated the association between infection with the parasite Ascaris allergic sensitization, and exercise-induced bronchospasm (EIB).

Objective

We sought to investigate the effect of Ascaris infection on bronchial hyperreactivity, skin testing, and specific IgE levels.

Methods

A cross-sectional prevalence survey was conducted in urban and rural South African children to measure levels of EIB. A sample of children was enrolled in a nested case-control study for further investigation based on response to exercise. Analyses used weighted logistic regression.

Results

Geometric mean total IgE levels were higher in Ascaris -infected subjects (infected su

SUBMITTER: Calvert J 

PROVIDER: S-EPMC4353837 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature