The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.

ABSTRACT:

Background

The Affymetrix Drug Metabolizing Enzymes and Transporters (DMET) Plus Premier Pack has been designed to genotype 1936 gene variants thought to be essential for screening patients in personalized drug therapy. These variants include the cytochrome P450s (CYP450s), the key metabolizing enzymes, many other enzymes involved in phase I and phase II pharmacokinetic reactions, and signaling mediators associated with variability in clinical response to numerous drugs not only among individuals, but also between ethnic populations.

Materials and methods

We genotyped 600 Saudi individuals for 1936 variants on the DMET platform to evaluate their clinical potential in personalized medicine in ethnic Arabs.

Results

Approximately 49% each of the 437 CYP450 variants, 56%

SUBMITTER: Wakil SM 

PROVIDER: S-EPMC4353852 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature