G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease.

ABSTRACT: G protein-coupled receptor 35 (GPR35) is an orphan receptor, discovered in 1998, that has garnered interest as a potential therapeutic target through its association with a range of diseases. However, a lack of pharmacological tools and the absence of convincingly defined endogenous ligands have hampered the understanding of function necessary to exploit it therapeutically. Although several endogenous molecules can activate GPR35 none has yet been confirmed as the key endogenous ligand due to reasons that include lack of biological specificity, non-physiologically relevant potency and species ortholog selectivity. Recent advances have identified several highly potent synthetic agonists and antagonists, as well as agonists with equivalent potency at rodent and human orthologs, which will be

SUBMITTER: Divorty N 

PROVIDER: S-EPMC4354270 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature