Developmental white matter microstructure in autism phenotype and corresponding endophenotype during adolescence.

ABSTRACT: During adolescence, white matter microstructure undergoes an important stage of development. It is hypothesized that the alterations of brain connectivity that have a key role in autism spectrum conditions (ASCs) may interact with the development of white matter microstructure. This interaction may be present beyond the phenotype of autism in siblings of individuals with ASC, who are 10 to 20 times more likely to develop certain forms of ASC. We use diffusion tensor imaging to examine how white matter microstructure measurements correlate with age in typically developing individuals, and how this correlation differs in n=43 adolescents with ASC and their n=38 siblings. Correlations observed in n=40 typically developing individuals match developmental changes noted in previous longitudinal

SUBMITTER: Lisiecka DM 

PROVIDER: S-EPMC4354353 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature