Serotonin versus catecholamine deficiency: behavioral and neural effects of experimental depletion in remitted depression.

ABSTRACT: Despite immense efforts into development of new antidepressant drugs, the increases of serotoninergic and catecholaminergic neurotransmission have remained the two major pharmacodynamic principles of current drug treatments for depression. Consequently, psychopathological or biological markers that predict response to drugs that selectively increase serotonin and/or catecholamine neurotransmission hold the potential to optimize the prescriber's selection among currently available treatment options. The aim of this study was to elucidate the differential symptomatology and neurophysiology in response to reductions in serotonergic versus catecholaminergic neurotransmission in subjects at high risk of depression recurrence. Using identical neuroimaging procedures with [(18)F] fluorodeoxygluco

SUBMITTER: Homan P 

PROVIDER: S-EPMC4354355 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature