Increased functional connectivity in the resting-state basal ganglia network after acute heroin substitution.

ABSTRACT: Reinforcement signals in the striatum are known to be crucial for mediating the subjective rewarding effects of acute drug intake. It is proposed that these effects may be more involved in early phases of drug addiction, whereas negative reinforcement effects may occur more in later stages of the illness. This study used resting-state functional magnetic resonance imaging to explore whether acute heroin substitution also induced positive reinforcement effects in striatal brain regions of protracted heroin-maintained patients. Using independent component analysis and a dual regression approach, we compared resting-state functional connectivity (rsFC) strengths within the basal ganglia/limbic network across a group of heroin-dependent patients receiving both an acute infusion of heroin and p

SUBMITTER: Schmidt A 

PROVIDER: S-EPMC4354356 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature