Sex differences in mania phenotype and ethanol consumption in the lateral hypothalamic kindled rat model.

ABSTRACT: Sex differences have been observed in mania phenotypes in humans. However the mechanisms underlying this difference are poorly understood. Activating the lateral hypothalamus is implicated in manic-like behaviors in rodents. Using newly established lateral hypothalamus kindled (LHK) rat mania model, we investigated sex differences of manic-like behaviors and its correlation with voluntary ethanol intake. We stimulated the lateral hypothalamus bilaterally in the male and female Wistar rats over five consecutive days. We recorded and quantified kindling-induced behaviors for each individual animal. We also assessed ethanol consumption using a two-bottle choice ethanol drinking as well as circadian locomotor activity counts daily throughout the experiment. We found notable sex differences in

SUBMITTER: Abulseoud OA 

PROVIDER: S-EPMC4354358 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature