Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.

ABSTRACT: Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4-7.5% of individuals with inflammatory bowel disease. We performed a genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2,962 controls, followed by replication in 1,025 PSC cases and 2,174 controls. We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 × 10⁻¹⁶ and P = 4.1 × 10⁻⁸, respectively).

SUBMITTER: Melum E 

PROVIDER: S-EPMC4354850 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature