Exposure to Leishmania braziliensis triggers neutrophil activation and apoptosis.

ABSTRACT:

Background

Neutrophils are the first line of defense against invading pathogens and are rapidly recruited to the sites of Leishmania inoculation. During Leishmania braziliensis infection, depletion of inflammatory cells significantly increases the parasite load whereas co-inoculation of neutrophils plus L. braziliensis had an opposite effect. Moreover, the co-culture of infected macrophages and neutrophils also induced parasite killing leading us to ask how neutrophils alone respond to an L. braziliensis exposure. Herein we focused on understanding the interaction between neutrophils and L. braziliensis, exploring cell activation and apoptotic fate.

Methods and findings

Inoculation of serum-opsonized L. braziliensis promastigotes in mice induced neutrophil accumulation in vi

SUBMITTER: Falcao SA 

PROVIDER: S-EPMC4354905 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature