Association of the colorectal CpG island methylator phenotype with molecular features, risk factors, and family history.

ABSTRACT:

Background

The CpG island methylator phenotype (CIMP) represents a subset of colorectal cancers characterized by widespread aberrant DNA hypermethylation at select CpG islands. The risk factors and environmental exposures contributing to etiologic heterogeneity between CIMP and non-CIMP tumors are not known.

Methods

We measured the CIMP status of 3,119 primary population-based colorectal cancer tumors from the multinational Colon Cancer Family Registry. Etiologic heterogeneity was assessed by a case-case study comparing risk factor frequency of colorectal cancer cases with CIMP and non-CIMP tumors using logistic regression to estimate the case-case odds ratio (ccOR).

Results

We found associations between tumor CIMP status and MSI-H (ccOR = 7.6), BRAF V600E mutation (c

SUBMITTER: Weisenberger DJ 

PROVIDER: S-EPMC4355081 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature