Impact of respiratory motion on worst-case scenario optimized intensity modulated proton therapy for lung cancers.

ABSTRACT:

Purpose

We compared conventionally optimized intensity modulated proton therapy (IMPT) treatment plans against worst-case scenario optimized treatment plans for lung cancer. The comparison of the 2 IMPT optimization strategies focused on the resulting plans' ability to retain dose objectives under the influence of patient setup, inherent proton range uncertainty, and dose perturbation caused by respiratory motion.

Methods and materials

For each of the 9 lung cancer cases, 2 treatment plans were created that accounted for treatment uncertainties in 2 different ways. The first used the conventional method: delivery of prescribed dose to the planning target volume that is geometrically expanded from the internal target volume (ITV). The second used a worst-case scenario optimiz

SUBMITTER: Liu W 

PROVIDER: S-EPMC4355168 | biostudies-literature | 2015 Mar-Apr

REPOSITORIES: biostudies-literature