Thymic stromal lymphopoietin signaling in CD4(+) T cells is required for TH2 memory.

ABSTRACT:

Background

Thymic stromal lymphopoietin (TSLP) is a key factor in the development of allergic asthma. Numbers of TH2 memory cells gradually increase in allergic patients with the progression of disease and persist in the lungs during remission, although the mechanism is not clear.

Objective

We sought to define the role of TSLP in TH2 memory cell generation and maintenance in vivo.

Methods

Adoptive transfer of wild-type and thymic stromal lymphopoietin receptor (TSLPR)-deficient ovalbumin-specific CD4(+) T cells before TH2 sensitization was used to define T cell-specific TSLP effects. Atopic dermatitis and increased serum TSLP concentrations were induced by topical application of the vitamin D3 analog MC903. Memory cells in peripheral blood were monitored weekly with f

SUBMITTER: Wang Q 

PROVIDER: S-EPMC4355221 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature