Therapeutic C3 inhibitor Cp40 abrogates complement activation induced by modern hemodialysis filters.

ABSTRACT: Approximately 350,000 individuals in the United States rely on maintenance hemodialysis treatment because of end-stage renal disease. Despite improvements in dialysis technology, the mortality rate for patients treated with maintenance dialysis is still exceptionally high, with a 5-year survival rate of only 35%. Many patients succumb to conditions resulting at least in part from the chronic induction of inflammation. Among the triggers of inflammation, the complement system is of particular importance, being a well-appreciated mediator of inflammatory processes that is involved in many pathologic states. Here we used a refined pre-clinical model of hemodialysis in cynomolgus monkeys to confirm that even modern, polymer-based hemodialysis filters activate complement and to evaluate the pot

SUBMITTER: Reis ES 

PROVIDER: S-EPMC4355228 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature