Leptin signaling is required for adaptive changes in food intake, but not energy expenditure, in response to different thermal conditions.

ABSTRACT: Survival of free-living animals depends on the ability to maintain core body temperature in the face of rapid and dramatic changes in their thermal environment. If food intake is not adjusted to meet the changing energy demands associated with changes of ambient temperature, a serious challenge to body energy stores can occur. To more fully understand the coupling of thermoregulation to energy homeostasis in normal animals and to investigate the role of the adipose hormone leptin to this process, comprehensive measures of energy homeostasis and core temperature were obtained in leptin-deficient ob/ob mice and their wild-type (WT) littermate controls when housed under cool (14°C), usual (22°C) or ∼ thermoneutral (30°C) conditions. Our findings extend previous evidence that WT mice robustly

SUBMITTER: Kaiyala KJ 

PROVIDER: S-EPMC4355297 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature