Pharmacokinetics and tolerability of oral sildenafil in adults with cystic fibrosis lung disease.

ABSTRACT:

Rationale

Airway inflammation is central to cystic fibrosis (CF) pathophysiology. Pre-clinical models have shown that phosphodiesterase inhibitors (PDEi) like sildenafil have anti-inflammatory activity. PDEi have not been studied in CF subjects.

Objectives

We evaluated the pharmacokinetics, tolerability, and safety of sildenafil in subjects with CF. Sputum biomarkers were used to explore efficacy.

Methods

An open-label pilot study of oral sildenafil administration was conducted in adults with mild to moderate CF lung disease. Subjects received oral sildenafil 20 or 40 mg p.o. t.i.d. for 6 weeks.

Measurements and main results

Twenty subjects completed the study. Estimated elimination rate constants were statistically different in subjects with CF compared to pre

SUBMITTER: Taylor-Cousar JL 

PROVIDER: S-EPMC4355330 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature