Tubulin- and actin-associating GIMAP4 is required for IFN-γ secretion during Th cell differentiation.

ABSTRACT: Although GTPase of the immunity-associated protein (GIMAP) family are known to be most highly expressed in the cells of the immune system, their function and role remain still poorly characterized. Small GTPases in general are known to be involved in many cellular processes in a cell type-specific manner and to contribute to specific differentiation processes. Among GIMAP family, GIMAP4 is the only member reported to have true GTPase activity, and its transcription is found to be differentially regulated during early human CD4(+) T helper (Th) lymphocyte differentiation. GIMAP4 has been previously connected mainly with T- and B-cell development and survival and T-cell apoptosis. Here we show GIMAP4 to be localized into cytoskeletal elements and with the component of the trans golgi network

SUBMITTER: Heinonen MT 

PROVIDER: S-EPMC4355353 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature