Common genetic variants on 6q24 associated with exceptional episodic memory performance in the elderly.

ABSTRACT:

Importance

There are genetic influences on memory ability as we age, but no specific genes have been identified.

Objective

To use a cognitive endophenotype, exceptional episodic memory (EEM) performance, derived from nondemented offspring from the Long Life Family Study (LLFS) to identify genetic variants that may be responsible for the high cognitive performance of LLFS participants and further replicate these variants using an additional 4006 nondemented individuals from 4 independent elderly cohorts.

Design, setting, and participants

A total of 467 LLFS participants from 18 families with 2 or more offspring that exhibited exceptional memory performance were used for genome-wide linkage analysis. Adjusted multivariate linear analyses in the 40-megabase region encomp

SUBMITTER: Barral S 

PROVIDER: S-EPMC4355405 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature