Pharmacokinetics and pharmacodynamics of propofol in cancer patients undergoing major lung surgery.

ABSTRACT: Despite the growing number of cancer cases and cancer surgeries around the world, the pharmacokinetics (PK) and pharmacodynamics (PD) of anesthetics used in this population are poorly understood. Patients operated due to cancer are usually in severe state and often require chemotherapy. It might affect the PK/PD of drugs used in this population. Therefore, in this study we explored the PK/PD of propofol in cancer patients having a major lung surgery. 23 patients that underwent a propofol-fentanyl total intravenous anesthesia were included in the analysis. A large set of demographic, biochemical and hemodynamic parameters was collected for the purpose of covariate analysis. Nonlinear mixed effect modeling in NONMEM was used to analyze the collected data. A three-compartment model was suffic

SUBMITTER: Przybylowski K 

PROVIDER: S-EPMC4355445 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature