Risk factors of hepatitis C virus transmission and genotype distribution in former blood donors from Chinese rural area.

ABSTRACT:

Background

Illegal commercial plasma and blood donation activities in the late 1980s and early 1990s caused a large number of hepatitis C virus (HCV) infections in rural areas of China. In the present study, we aimed to elucidate the risk factors of HCV RNA positivity and HCV genotype distribution in former blood donors.

Methods

A cross-sectional survey was carried out in a former blood donation village in rural Hebei Province, North China. All residents were invited for a questionnaire interview and testing for HCV antibodies as well as HCV nucleic acids. Questionnaires were administered to collect information about their personal status and commercial blood donation history. Nested PCR was used to amplify HCV nucleic acids in C/E1 region and NS5b region followed by genotyp

SUBMITTER: Yin W 

PROVIDER: S-EPMC4355568 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature