Simultaneous and dose dependent melanoma cytotoxic and immune stimulatory activity of betulin.

ABSTRACT: Conventional cytostatic cancer treatments rarely result in the complete eradication of tumor cells. Therefore, new therapeutic strategies focus on antagonizing the immunosuppressive activity of established tumors. In particular, recent studies of antigen-loaded dendritic cells (DCs) eliciting a specific antitumor immune response has raised the hopes of achieving the complete elimination of tumor tissue. Genistein, fingolimod and betulin have already been described as active compounds in different types of cancer. Herein, we applied an integrated screening approach to characterize both their cytostatic and their immune-modulating properties side-by-side. As will be described in detail, our data confirmed that all three compounds exerted proapoptotic and antiproliferative activity in differe

SUBMITTER: Pfarr K 

PROVIDER: S-EPMC4355578 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature