Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells.

ABSTRACT:

Background

Balanced activation and inhibition of the immune system ensures pathogen clearance while avoiding hyperinflammation. Siglecs, sialic acid-binding proteins found on subsets of immune cells, often inhibit inflammation: Siglec-8 on eosinophils and Siglec-9 on neutrophils engage sialoglycan ligands on airways to diminish ongoing inflammation. The identities of human siglec ligands and their expression during inflammation are largely unknown.

Objective

The histologic distribution, expression, and molecular characteristics of siglec ligands were explored in healthy and inflamed human upper airways and in a cellular model of airway inflammation.

Methods

Normal and chronically inflamed upper airway tissues were stained for siglec ligands. The ligands were extracted

SUBMITTER: Jia Y 

PROVIDER: S-EPMC4355580 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature