A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma.
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ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC4355672 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma.
Zhang Weijian W Zhou Lina L Yin Peiyuan P Wang Jinbing J Lu Xin X Wang Xiaomei X Chen Jianguo J Lin Xiaohui X Xu Guowang G
Scientific reports 20150311
Dynamic metabolomics studies can provide a systematic view of the metabolic trajectory during disease development and drug treatment and reveal the nature of biological processes at metabolic level. To extract important information in a systematic time dimension rather than at isolated time points, a weighted method based on the means and variations along the time points was proposed and first applied to previously published rat model data. The method was subsequently extended and applied to pro ...[more]
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