Interaction with the effector dynamin-related protein 1 (Drp1) is an ancient function of Rab32 subfamily proteins.

ABSTRACT: The mitochondria-associated membrane (MAM) is an endoplasmic reticulum (ER) domain that forms contacts with mitochondria and accommodates Ca²⁺ transfer between the two organelles. The GTPase Rab32 regulates this function of the MAM via determining the localization of the Ca²⁺ regulatory transmembrane protein calnexin to the MAM. Another function of the MAM is the regulation of mitochondrial dynamics mediated by GTPases such as dynamin-related protein 1 (Drp1). Consistent with the importance of the MAM for mitochondrial dynamics and the role of Rab32 in MAM enrichment, the inactivation of Rab32 leads to mitochondrial collapse around the nucleus. However, Rab32 and related Rabs also perform intracellular functions at locations other than the MAM including melanosomal tr

SUBMITTER: Ortiz-Sandoval CG 

PROVIDER: S-EPMC4355727 | biostudies-literature | 2014 Oct-Dec

REPOSITORIES: biostudies-literature