Herpes simplex virus type 1 in peptic ulcer disease: an inverse association with Helicobacter pylori.

ABSTRACT:

Aim

To assess the frequency of herpes simplex virus type I in upper gastrointestinal tract ulcers and normal mucosa with the modern and better assays and also with a larger number of well characterized patients and controls and its relationship to Helicobacter pylori(H pylori).

Methods

Biopsy specimens from 90 patients (34 with gastric ulcer of the prepyloric area and 56 with duodenal ulcer) were evaluated. Biopsies from 50 patients with endoscopically healthy mucosa were considered as the control group. The method used to identify herpes simplex virus-1 (HSV-1) was polymerase chain reaction. H pylori was detected by the CLO-test and by histological method.

Results

Herpes simplex virus-1 was detected in 28 of 90 patients with peptic ulcer (31%) [11 of 34 patients with

SUBMITTER: Tsamakidis K 

PROVIDER: S-EPMC4355758 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature