Cytochrome P450 2E1 high activity polymorphism in alcohol abuse and end-organ disease.

ABSTRACT:

Aim

To investigate a possible role for a recently identified polymorphism in the gene of cytochrome P450 2E1, the presence of which is associated with high activity of the enzyme.

Methods

Two hundred and thirty-nine alcohol consumers, ICD 10.1/.2 (ALC), and 208 normal controls were studied. PCR amplification of the CYP2E1 gene region was performed to assess polymorphic variation. Fisher's exact test was used to assess the data.

Results

Twelve normal controls (5.8%) possessed the insertion. Five ALC (2.1%) had the insertion; of these 2 of 144 with alcohol induced chronic pancreatitis, none of 28 with alcoholic liver disease and 3 of 67 without end-organ disease had the polymorphism. A significantly Lower frequency of subjects possessed the insertion than normal control

SUBMITTER: Cartmell MT 

PROVIDER: S-EPMC4355784 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature