Sustained sleep fragmentation induces sleep homeostasis in mice.

ABSTRACT:

Study objectives

Sleep fragmentation (SF) is an integral feature of sleep apnea and other prevalent sleep disorders. Although the effect of repetitive arousals on cognitive performance is well documented, the effects of long-term SF on electroencephalography (EEG) and molecular markers of sleep homeostasis remain poorly investigated. To address this question, we developed a mouse model of chronic SF and characterized its effect on EEG spectral frequencies and the expression of genes previously linked to sleep homeostasis including clock genes, heat shock proteins, and plasticity-related genes.

Design

N/A.

Setting

Animal sleep research laboratory.

Participants

Sixty-six C57BL6/J adult mice.

Interventions

Instrumental sleep disruption at a rate of 60/h dur

SUBMITTER: Baud MO 

PROVIDER: S-EPMC4355896 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature